Multiple sclerosis as the flip side of immune fitness

About half of the people with multiple sclerosis have the HLA-DR15 gene variant. A study has now shown how this genetic predisposition contributes to the development of the autoimmune disease multiple sclerosis in combination with environmental factors. The decisive factor is the shaping of a repertoire of immune cells which – although they are effective in fighting off pathogens such as Epstein-Barr virus – also attack brain tissue.

New anti-AB vaccine could help halt Alzheimer’s progression, preclinical study finds

A preclinical study by neuroscientists indicates that an antigen-presenting dendritic vaccine with a specific antibody response to oligomeric A-beta may be safer and offer clinical benefit in treating Alzheimer’s disease. The vaccine uses immune cells known as dendritic cells loaded with a modified A beta peptide as the antigen.