A new study reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM). The researchers also discovered that when BAP1 is lost, …
Off-the-shelf artificial cardiac patch repairs heart attack damage in rats, pigs
Researchers have developed an ‘off-the-shelf’ artificial cardiac patch that can deliver cardiac cell-derived healing factors directly to the site of heart attack injury.
Drug shows promise in reversing kidney damage caused by lupus
A drug used for cancer therapy has shown promise in reversing kidney damage caused by systemic lupus erythematosus (SLE, or lupus), according to a Yale-led study published April 8 in the journal Science Translational Medicine.
Exploring mechanisms of resistance to HIV in people with sickle cell disease
A new analysis supports prior reports that people with sickle cell disease have lower rates of human immunodeficiency virus (HIV) infection, but follow-up cell studies did not reveal a mechanism to explain the reduced risk.
Cancer mutation in dual role
Analyses of cell signals provide insight into the origin of severe inflammatory symptoms that appear in various types of blood cancer and point to possible therapeutic approaches: In around one-fourth of patients suffering from juvenile myelomonocytic …
Is autoimmunity on the rise?
A study provides evidence that the prevalence of autoimmunity — when the immune system goes awry and attacks the body itself — has increased in the United States in recent years.