The human immune system is a finely-tuned machine, balancing when to release a cellular army to deal with pathogens, with when to rein in that army, stopping an onslaught from attacking the body itself. Now, researchers have discovered a way to control…
Age-related impairments reversed in animal model
Frailty and immune decline are two main features of old age. Researchers now demonstrate in an animal model that these two age-related impairments can be halted and even partially reversed using a novel cell-based therapeutic approach.
Location, location, location: Even gut immune response is site-specific
Researchers are using mini-organs to model the digestive tract in the laboratory. These so-called organoids provide insights into the inflammatory processes that play a role in diseases such Crohn’s and ulcerative colitis.
In mouse study, black raspberries show promise for reducing skin inflammation
In a study done with mice, researchers found that a diet high in black raspberries reduced inflammation from contact hypersensitivity — a condition that causes redness and inflammation in the skin.
Proteins Tet2 and Tet3: key regulators of B cell activity and autoimmunity
Researchers have identified the epigenetic proteins Tet2 and Tet3 as key regulators of B cell function. They showed that these proteins suppress B cell function and conversely, that Tet2/Tet3 knockout mice develop a mild form of systemic lupus erythema…
Smart structures: Structural cells of the body control immune function
Researchers analyzed the epigenetic and transcriptional regulation in structural cells. They found widespread activity of immune genes, suggesting that structural cells are deeply involved in the body’s response to pathogens. Moreover, the study uncove…