A new therapy for influenza virus infections that may also prove effective against many other pathogenic virus infections, including HIV and COVID-19, has been developed by scientists. The team’s approach uses a targeted therapy approach against the vi…
Therapeutic PD-1 cancer vaccine shown to be safe and effective in animal study
A study has described a potential therapeutic anticancer vaccine that frees suppressed cancer-killing immune cells, enabling them to attack and destroy a tumor.
Boosting stem cell activity can enhance immunotherapy benefits
Immune-system T cells have been reprogrammed into regenerative stem cell-like memory (TSCM) cells that are long-lived, highly active ‘super immune cells’ with strong antitumor activity, according to new research.
Altered ‘coat’ disguises fatal brain virus from neutralizing antibodies
A genetic modification in the ‘coat’ of a brain infection-causing virus may allow it to escape antibodies, according to researchers. They say testing people for this and other viral mutations may help identify patients at risk for developing a fatal br…
T-cell abnormalities in severe COVID-19 cases
Researchers performed a genetic analysis of T cells from lung tissue of COVID-19 patients. They found abnormalities that resulted in T cell overreaction that may cause severe pneumonia.
How tissue geometry influences the movement of cells through the body
Cells move constantly throughout our bodies, performing myriad operations critical to tissue development, immune responses and general wellbeing. This bustle is guided by chemical cues long studied by scientists interested in cellular migration.
Engineered immune cells elicit broad response to HIV in mice, offering hope for vaccine
Unlike so many other deadly viruses, HIV still lacks a vaccine. The virus has proven especially tricky to prevent with conventional antibodies, in part because it evolves so rapidly in the body. A solution would require coaxing the body into producing …
Stem cell transplantation: Undesirable rejection mechanism identified
In the treatment of leukemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions – especially in the skin or in the gut, since these so-called barrier organs are more frequently a…
In the lab, scientists identify possible COVID-19 treatment
Immunologists have determined the process driving life-threatening inflammation, lung damage and organ failure in patients with COVID-19, sepsis and other inflammatory disorders suggesting possible treatment using existing drugs.
Brain protein could be starting point for new treatments for pancreatic cancer
Researchers have discovered that a protein thought to only be involved in the development of neurons in the brain also plays a major role in the development and growth of pancreatic cancer. Their findings demonstrate for the first time how the protein,…