Despite a similar clinical presentation, people with severe asthma have strikingly distinct immune profiles, research shows. These findings can be used to develop new therapeutics and enhance precision medicine approaches to treating these patients.
Study reveals cancer immunotherapy patients at most risk of life-threatening side effects
Immune checkpoint inhibitors boost a patient’s immune response against cancer cells, but they can cause potentially life-threatening side effects in some individuals. New research may help clinicians determine which patients are most at risk.
Study reveals crucial details on skin-related side effects of cancer immune therapies
Immune checkpoint inhibitors are life-saving therapies against advanced cancer, but they can cause side effects, most commonly involving the skin. New research provides insights on the extent of these side effects, when they tend to arise, and which pa…
Novel immunotherapy approach to fight melanoma
Researchers have advanced a tumor-targeting and cell penetrating antibody that can deliver payloads to stimulate an immune response to help treat melanoma.
Activating the brain’s immune system against cancer prevents it from spreading, research finds
Researchers have identified a failure in the brain’s immune system that can lead to the amplification of cell division and spread of glioblastoma cancer cells.
Personalized cancer vaccine deemed safe, shows potential benefit against cancer
A personalized cancer vaccine raised no safety concerns and showed potential benefit in patients with different cancers, including lung and bladder, that have a high risk of recurrence, according to results from an investigator-initiated phase I clinic…
Immune-stimulating drug before surgery shows promise in early-stage pancreatic cancer
Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study.
Interleukin-33 involved in immunity to Sars-CoV-2
A new study reveals the involvement of interleukin-33, an important alarm signal, when immune cells get exposed to Sars-CoV-2 for a second time.
COVID-19 causes ‘unexpected’ cellular response in the lungs, research finds
Scientists have discovered a surprising response in lung cells infected with the SARS-CoV-2 virus, which might explain why the disease is so difficult to treat. The researchers suggest testing a new pairing of drugs to combat the disease.
Two studies support key role for immune system in shaping SARS-CoV-2 evolution
Two studies provide new evidence supporting an important role for the immune system in shaping the evolution of SARS-CoV-2, the virus that causes COVID-19.