Researchers have shown that the L452R mutation of the SARS-CoV-2 spike protein, which is common to two variants (Epsilon and Delta), is involved in cellular immunity evasion via the human leukocyte antigen (HLA) A24, and enhances viral infectivity.
No IgA leads to intestinal inflammation in mice
Researchers have found that immunoglobulin A (IgA) deficiency leads to disruption of the ileal gut microbiota and increased inflammation in the ileum in mice. This suggests that IgA plays an important role in mucosal homeostasis by regulating the intes…
Novel autoantibody adds fuel to COVID-19 ‘firestorm’ of inflammation, blood clots
Researchers have discovered another functional autoantibody in COVID-19 patients that contributes to the disease’s development and the ‘firestorm’ of blood clots and inflammation it induces. The autoantibody makes it much harder for the body to degrade…
Study shows why second dose of COVID-19 vaccine shouldn’t be skipped
The second dose of a COVID-19 vaccine induces a powerful boost to a part of the immune system that provides broad antiviral protection, according to a new study.
Simple compound to control complex gut microbes
Researchers have discovered that acetate, a major metabolite produced by some intestinal bacteria, is involved in regulating other intestinal bacteria. Experiments specifically showed that acetate could trigger an immune response against potentially ha…
When mad AIOLOS drags IKAROS down: A novel pathogenic mechanism
Researchers have described a novel primary immunodeficiency due to a mutation in AIOLOS. This acts through a novel pathogenic mechanism termed ‘heterodimeric interference’, whereby when two different proteins bind together in a heterodimer, the mutant …
New theory suggests blood immune and clotting components could contribute to psychosis
A scientific review has found evidence that a disruption in blood clotting and the first line immune system could be contributing factors in the development of psychosis.
New UK study reveals extent of brain complications in children hospitalized with COVID-19
Although the risk of a child being admitted to hospital due to COVID-19 is small, a new UK study has found that around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection.
Human cells harness power of detergents to wipe out bacteria
Researchers have discovered that a molecule found within many of the body’s cells kills germs by dissolving their protective membranes.
T-cell ‘training grounds’ behind robust immune system response seen in adenovirus vaccines
Adenovirus vaccine vectors, such as the ChAdOx1 nCov-19 construct which has risen to prominence as a major vaccine for COVID-19, may generate robust long-term immune system responses, according to scientists.