As an autoimmune disease, Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy.
New review highlights cancer-crushing viruses
In a recent review article researchers describe a class of viruses that act to combat rather than cause deadly disease. Such oncolytic viruses as they are known, have a remarkable ability to target and destroy cancer cells, while leaving healthy cells …
Successful treatment in mice for severe childhood cancer
In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study shows. This is a vital step toward a potentially curative treatment for a form of cancer affecting young childr…
Grouping of immune cell receptors could help decode patients’ personal history of infection
Novel software for grouping immunological T-cell receptors may enable the identification of shared patterns that could be used to determine if a person has previously been infected or vaccinated against a given pathogen.
Which glioblastoma patients will respond to immunotherapy?
Scientists have discovered a new biomarker to identify which patients with brain tumors called glioblastomas — the most common and malignant of primary brain tumors — might benefit from immunotherapy. The treatment could extend survival for an estima…
Potential new therapeutic pathway to clear chronic viral infections
A recent study in mice has uncovered that during chronic viral infection, a protein called BMI-1 gets turned on too early in B cells and messes up the delicate balance of gene expression, resulting in antibodies that are unsuccessful in their endeavor …
Antibodies mimicking the virus may explain long haul COVID-19, rare vaccine side effects, study suggests
A new article suggests that secondary antibodies known as ‘anti-idiotype antibodies’ could be responsible for some of the side effects of COVID-19 vaccines and the symptoms of long-haul COVID.
Researchers find new link between a disrupted body clock and inflammatory diseases
New research has demonstrated the significant role that an irregular body clock plays in driving inflammation in the body’s immune cells, with implications for the most serious and prevalent diseases in humans.
Antihistamines can influence immunotherapy response by enhancing T cell activation
Researchers discovered that antihistamines are associated with improved responses to immunotherapy. Their work revealed a role for the histamine receptor in suppressing T cell activation to block anti-tumor immune responses.
Experimental compound counters diabetic complications
An experimental compound reduced complications of type 1 and type 2 diabetes in mice — not by lowering blood sugar — but by countering its consequences, a new study finds.