An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells in the immediate vicinity of the tumor, leading to a reduction in tumor growth, and in some mice, eliminating thei…
Machine learning model uses clinical and genomic data to predict immunotherapy effectiveness
A new machine learning model accurately predicts whether immune checkpoint blockade (ICB), a growing class of immunotherapy drugs, will be effective in patients diagnosed with a wide variety of cancers. The forecasting tool assesses multiple patient-sp…
Researchers identify molecule that blocks immune cells from entering and killing breast tumors
Researchers have identified a key molecule in certain kinds of breast cancers that prevent immune cells from entering tumors and killing the cancer cells inside. This research could pave the way toward a new treatment for certain kinds of aggressive br…
Novel drug liberates tumor vessels to aid cancer drug delivery
A therapeutic antibody has been shown to unblock and normalize blood vessels inside cancerous tumors, enabling the more effective delivery of targeted cancer treatments.
Inflammatory cytokine levels may predict outcomes in orthopedic trauma patients
Inflammatory cytokines are molecules that are secreted by immune cells to promote inflammation. A study found that measuring inflammatory cytokines may help predict patient outcomes after traumatic injury, which is the leading cause of mortality in ind…
A commonly found parasite could treat certain types of cancer, say scientists
Scientists have discovered that a deadly parasite, known to cause ill health in pregnant women and immunocompromised patients, could potentially be used to treat various types of tumors.
Antibody treatment prevents inflammation in lungs, nervous system in macaques with SARS-CoV-2, study finds
Monoclonal antibodies protected aged, diabetic rhesus macaque monkeys from disease due to SARS-CoV-2 and reduced signs of inflammation, including in cerebrospinal fluid, according to a new study.
New potential drug target for pneumonia
Researchers report that a recently discovered inflammatory mediator, interleukin-26, appears to have an important role in pneumonia and contribute to the killing of bacteria.
How COVID-19 alters the immune system
COVID-19 reduces the numbers and functional competence of certain types of immune cells in the blood, say researchers. This could affect responses to secondary infections.
A mathematical model to help optimize vaccine development
Scientists are using a mathematical model to better understand the immune response to vaccines.