Among patients with advanced cancer who were prescribed immune checkpoint inhibitors, those who experienced skin-related side effects were significantly less likely to die. The findings may help clinicians counsel patients who develop skin-related side…
‘Kick and kill’ strategy aimed at eliminating HIV-infected cells
In a study using mice, a team of researchers has improved upon a method they developed in 2017 that was designed to kill HIV-infected cells. The advance could move scientists a step closer to being able to reduce the amount of virus, or even eliminate …
Alzheimer’s: Inflammatory markers are conspicuous at an early stage
Long before the onset of dementia, there is evidence for increased activity of the brain’s immune system. Researchers from DZNE and the University Hospital Bonn (UKB) come to this conclusion based on a study of more than 1,000 older adults. To this end…
New study reveals how the lung’s immune cells develop after birth
From our first breath, our lungs are exposed to microorganisms, such as bacteria and viruses. Thanks to immune cells in the lungs, so-called macrophages, we are protected from most infections at an early age. Researchers now show how lung macrophages d…
Tomato concentrate could help reduce chronic intestinal inflammation associated with HIV
New research in mice suggests that adding a certain type of tomato concentrate to the diet can reduce the intestinal inflammation that is associated with HIV. Left untreated, intestinal inflammation can accelerate arterial disease, which in turn can le…
Mechanism controlling tertiary lymphoid structure formation in tumors discovered
Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures. However, little is known about how tertiary lympho…
Behind enemy lines: Research finds a new ally in the fight against cardiovascular disease hidden within the vessel wall itself
Researchers have discovered a new role for macrophages in the fight against cardiovascular disease. Macrophages have mostly been thought to drive inflammation and promote plaque build-up, but a new study shows that a subset of macrophages is actually f…
Researchers identify signaling mechanisms in pancreatic cancer cells that could provide treatment targets
Scientists have provided new insights into molecular ‘crosstalk’ in pancreas cancer cells, identifying vulnerabilities that could provide a target for therapeutic drugs already being studied in several cancers.
Researchers develop new method to increase effectiveness of nanomedicines
Researchers have discovered a new, more effective method of preventing the body’s own proteins from treating nanomedicines like foreign invaders, by covering the nanoparticles with a coating to suppress the immune response that dampens the therapy’s ef…
Scientists discover how key protein drives our immune response against viruses
New research reveals a target for therapies that could improve anti-viral responses in some patients and reduce autoimmune problems in others when immune responses run out of control.