A new study shows that a diet rich in isoflavone, a phytoestrogen or plant-based compound that resembles estrogen, protects against multiple sclerosis-like symptoms in a mouse model of the disease. Importantly, the isoflavone diet was only protective w…
‘Clock’ created to predict immunological health and chronic diseases of aging
Researchers have created an inflammatory clock of aging (iAge) which measures inflammatory load and predicts multi-morbidity, frailty, immune health, cardiovascular aging and is also associated with exceptional longevity in centenarians.
A fermented-food diet increases microbiome diversity and lowers inflammation, study finds
A diet rich in fermented foods enhances the diversity of gut microbes and decreases molecular signs of inflammation, according to researchers.
Progress towards new treatments for tuberculosis
A new study has uncovered how cells infected with tuberculosis bacteria can die, and that using new medicines to enhance particular forms of cell death decreased the severity of the disease in a preclinical model.
Sensing ‘junk’ RNA after chemotherapy enhances blood regeneration
Scientists reveal that during hematopoietic regeneration, RNA expressed from a part of the genome considered ‘junk DNA’ is used by hematopoietic stem cells to get activated and proliferate. The study shows that these so-called transposable elements mak…
Scientists blueprint bacterial enzyme believed to ‘stealthily’ suppress immune response
Scientists have produced the first fine-detail molecular blueprints of a bacterial enzyme known as Lit, which is suspected to play a ‘stealthy’ role in the progression of infection by reducing the immune response. Blueprints such as these allow drug de…
Anti-tumor agent from the intestine
Certain metabolites of bacteria from the intestine make immune cells more aggressive as a new study conducted by scientists reveals. The findings could help improve cancer therapies.
Biomaterial vaccines ward off broad range of bacterial infections and septic shock
Researchers have developed a biomaterial-based infection vaccine (ciVAX) approach as a solution that could be broadly applied to challenges in infection medicine.
Potential marker for success of immunotherapy in the treatment of lung cancer
Lung cancer has the highest mortality rate of all cancers, and treatment options are extremely limited, especially for patients with oncogenic mutations in the KRAS gene. Some patients respond very well to treatment with immune checkpoint inhibitors wh…
Discovery shows how tuning the immune system may enhance vaccines and ease disease
A metabolic control pathway that regulates T follicular helper cells offers targets for drugs to stimulate the adaptive immune response.