A new study reveals the involvement of interleukin-33, an important alarm signal, when immune cells get exposed to Sars-CoV-2 for a second time.
COVID-19 causes ‘unexpected’ cellular response in the lungs, research finds
Scientists have discovered a surprising response in lung cells infected with the SARS-CoV-2 virus, which might explain why the disease is so difficult to treat. The researchers suggest testing a new pairing of drugs to combat the disease.
Two studies support key role for immune system in shaping SARS-CoV-2 evolution
Two studies provide new evidence supporting an important role for the immune system in shaping the evolution of SARS-CoV-2, the virus that causes COVID-19.
STING gene methylation allows melanoma to evade the immune system
Researchers demonstrate how an important defect in STING gene expression in melanoma cells contributes to their evasion from immune cell detection and destruction.
A drug that can stop tumors from growing
Scientists detail new work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and th…
First images of cells exposed to COVID-19 vaccine reveal native-like coronavirus spikes
New research has for the first time compared images of the protein spikes that develop on the surface of cells exposed to the Oxford-AstraZeneca vaccine to the protein spike of the SARS-CoV-19 coronavirus. The images show that the spikes are highly sim…
Software package enables deeper understanding of cancer immune responses
Researchers have developed DeepTCR, a software package that employs deep-learning algorithms to analyze T-cell receptor (TCR) sequencing data.
Unravelling the secret of a critical immune cell for cancer immunity
Researchers have discovered a key differentiation process that provides an essential immune function in helping to control cancer and infectious diseases. The research shows that a new factor – DC-SCRIPT – is required for the function a particular type…
Understanding itch: New insights at the intersection of the nervous system and immune system
Researchers offer new clues about the underlying mechanisms of itch. Findings suggest a key molecular player known as cysteine leukotriene receptor 2 (CysLT2R) that may be a new target for intractable chronic itch.
Replacing what was lost: A novel cell therapy for type I diabetes mellitus
Researchers have developed a novel device for the safe and effective transplantation of human pancreatic beta-cells in type I diabetes mellitus (T1D). By constructing a millimeter-thick graft encapsulating beta-cells and transplanting it in diabetic mi…