Researchers have developed a novel device for the safe and effective transplantation of human pancreatic beta-cells in type I diabetes mellitus (T1D). By constructing a millimeter-thick graft encapsulating beta-cells and transplanting it in diabetic mice, they were able to show that the device was removable for up to 1 year and without a significant foreign body response. This study demonstrates a novel option for cell therapy for T1D.