Researchers demonstrate how an important defect in STING gene expression in melanoma cells contributes to their evasion from immune cell detection and destruction.
A drug that can stop tumors from growing
Scientists detail new work on NLRP3, an intracellular complex that has been found to participate in melanoma-mediated inflammation, leading to tumor growth and progression. By inhibiting NLRP3, the researchers found, they can reduce inflammation and th…
First images of cells exposed to COVID-19 vaccine reveal native-like coronavirus spikes
New research has for the first time compared images of the protein spikes that develop on the surface of cells exposed to the Oxford-AstraZeneca vaccine to the protein spike of the SARS-CoV-19 coronavirus. The images show that the spikes are highly sim…
Software package enables deeper understanding of cancer immune responses
Researchers have developed DeepTCR, a software package that employs deep-learning algorithms to analyze T-cell receptor (TCR) sequencing data.
Unravelling the secret of a critical immune cell for cancer immunity
Researchers have discovered a key differentiation process that provides an essential immune function in helping to control cancer and infectious diseases. The research shows that a new factor – DC-SCRIPT – is required for the function a particular type…
Understanding itch: New insights at the intersection of the nervous system and immune system
Researchers offer new clues about the underlying mechanisms of itch. Findings suggest a key molecular player known as cysteine leukotriene receptor 2 (CysLT2R) that may be a new target for intractable chronic itch.
Replacing what was lost: A novel cell therapy for type I diabetes mellitus
Researchers have developed a novel device for the safe and effective transplantation of human pancreatic beta-cells in type I diabetes mellitus (T1D). By constructing a millimeter-thick graft encapsulating beta-cells and transplanting it in diabetic mi…
Possible trigger for Crohn’s disease identified
AIEC bacteria grow in a biofilm that coats cells lining the intestinal wall, protecting them from both the immune system and antibiotics. In this research, the team identified a critical protein structure on the surface of the bacteria that allow them …